BOC (gene) explained

Brother of CDO is a protein that in humans is encoded by the BOC gene.^{[1] [2]}

CDON (MIM 608707) and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII; see MIM 135600) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM]

Interactions

BOC (gene) has been shown to interact with CDON.

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Kang JS, Feinleib JL, Knox S . Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 7 . 3989–94 . 2003 . 12634428 . 10.1073/pnas.0736565100 . 153035 . 2003PNAS..100.3989K . etal. free .
• Wegorzewska M, Krauss RS, Kang JS . Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. . Mol. Carcinog. . 37 . 1 . 1–4 . 2003 . 12720294 . 10.1002/mc.10121 . 46652847 .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Kang JS, Yi MJ, Zhang W . Netrins and neogenin promote myotube formation. . J. Cell Biol. . 167 . 3 . 493–504 . 2004 . 15520228 . 10.1083/jcb.200405039 . 2172498 . etal.
• Tenzen T, Allen BL, Cole F . The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. . Dev. Cell . 10 . 5 . 647–56 . 2006 . 16647304 . 10.1016/j.devcel.2006.04.004 . etal. free .

Notes and References

1. Kang JS, Mulieri PJ, Hu Y, Taliana L, Krauss RS . BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation . EMBO J . 21 . 1–2 . 114–24 . Jan 2002 . 11782431 . 125805 . 10.1093/emboj/21.1.114 .
2. Web site: Entrez Gene: BOC Boc homolog (mouse).