BMP binding endothelial regulator explained

BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene.^[1]

Transcription

KLF15 is a strong and direct activator of BMPER expression which is inhibited by SP1. BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15.^[2]

Further reading

• Nagase T, Kikuno R, Ohara O . Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins . DNA Research . 8 . 6 . 319–27 . Dec 2001 . 11853319 . 10.1093/dnares/8.6.319 . free .
• Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C . BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation . Molecular and Cellular Biology . 23 . 16 . 5664–79 . Aug 2003 . 12897139 . 166349 . 10.1128/MCB.23.16.5664-5679.2003 .
• Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F . Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins . Biochemical and Biophysical Research Communications . 315 . 2 . 272–80 . Mar 2004 . 14766204 . 10.1016/j.bbrc.2004.01.048 .
• Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib A, Augustin H, Bode C, Patterson C, Moser M . BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis . Circulation Research . 103 . 8 . 804–12 . Oct 2008 . 18787191 . 10.1161/CIRCRESAHA.108.178434 . free .
• Funari VA, Krakow D, Nevarez L, Chen Z, Funari TL, Vatanavicharn N, Wilcox WR, Rimoin DL, Nelson SF, Cohn DH . BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing . American Journal of Human Genetics . 87 . 4 . 532–7 . Oct 2010 . 20869035 . 2948790 . 10.1016/j.ajhg.2010.08.015 .

Notes and References

1. Web site: Entrez Gene: BMP binding endothelial regulator. 2011-09-29 .
2. Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M . Krüppel-like factor 15 regulates BMPER in endothelial cells . Cardiovascular Research . 85 . 3 . 551–9 . Feb 2010 . 19767294 . 10.1093/cvr/cvp314 . 4110462 .