BIRC6 explained

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.^{[1] [2]}

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.^[2]

Interactions

BIRC6 has been shown to interact with KIF23.^[3]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers^[4] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology^[5]).

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 . .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 5 . 337–45 . 2000 . 10574462 . 10.1093/dnares/6.5.337 . free .
• Qiu XB, Markant SL, Yuan J, Goldberg AL . Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. . EMBO J. . 23 . 4 . 800–10 . 2005 . 14765125 . 380992 . 10.1038/sj.emboj.7600075 .
• Bartke T, Pohl C, Pyrowolakis G, Jentsch S . Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. . Mol. Cell . 14 . 6 . 801–11 . 2005 . 15200957 . 10.1016/j.molcel.2004.05.018 . free .
• Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M . Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. . Nat. Cell Biol. . 6 . 9 . 849–60 . 2004 . 15300255 . 10.1038/ncb1159 . 22850781 .
• Wu X, Yen L, Irwin L, Sweeney C, Carraway KL . Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. . Mol. Cell. Biol. . 24 . 17 . 7748–57 . 2004 . 15314180 . 506982 . 10.1128/MCB.24.17.7748-7757.2004 .
• Qiu XB, Goldberg AL . The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. . J. Biol. Chem. . 280 . 1 . 174–82 . 2005 . 15507451 . 10.1074/jbc.M411430200 . free .

Notes and References

1. Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T . A human IAP-family gene, apollon, expressed in human brain cancer cells . Biochem Biophys Res Commun . 264 . 3 . 847–54 . Dec 1999 . 10544019 . 10.1006/bbrc.1999.1585 .
2. Web site: Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon).
3. Pohl C, Jentsch S . Final stages of cytokinesis and midbody ring formation are controlled by BRUCE . Cell . 132 . 5 . 832–45 . Mar 2008 . 18329369 . 10.1016/j.cell.2008.01.012 . 12192141 . free .
4. Web site: BIRC6 (Baculoviral IAP repeat-containing 6). atlasgeneticsoncology.org.
5. Web site: Atlas of Genetics and Cytogenetics in Oncology and Haematology. atlasgeneticsoncology.org.