BCL7A explained

B-cell CLL/lymphoma 7 protein family member A is a protein that in humans is encoded by the BCL7A gene located in the chromosome 12 (Cytogenetic band: 12q24.31).^[1]

Function

This gene codifies for a protein that belongs to the SWI/SNF chromatin remodelling complex, a complex that is able to modify the interations between DNA and histones using the energy of the ATP hydrolysis. It has found recurrently mutated in lymphomas^[2] and silenced by promoter hypermetylation in haematological malignancies.^{[3] [4]}

See also

• B-cell lymphoma

Further reading

• van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP . Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73 . J. Clin. Oncol. . 23 . 17 . 3886–96 . 2005 . 15897551 . 10.1200/JCO.2005.11.353 . free .
• Carbone A, Bernardini L, Valenzano F, Bottillo I, De Simone C, Capizzi R, Capalbo A, Romano F, Novelli A, Dallapiccola B, Amerio P . Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF . Genes Chromosomes Cancer . 47 . 12 . 1067–75 . 2008 . 18663754 . 10.1002/gcc.20601 . 205827302 .
• Morton LM, Purdue MP, Zheng T, Wang SS, Armstrong B, Zhang Y, Menashe I, Chatterjee N, Davis S, Lan Q, Vajdic CM, Severson RK, Holford TR, Kricker A, Cerhan JR, Leaderer B, Grulich A, Yeager M, Cozen W, Hoar Zahm S, Chanock SJ, Rothman N, Hartge P . Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development . Cancer Epidemiol. Biomarkers Prev. . 18 . 4 . 1259–70 . 2009 . 19336552 . 2716008 . 10.1158/1055-9965.EPI-08-1037 .
• Morton LM, Purdue MP, Zheng T, Wang SS, Armstrong B, Zhang Y, Menashe I, Chatterjee N, Davis S, Lan Q, Vajdic CM, Severson RK, Holford TR, Kricker A, Cerhan JR, Leaderer B, Grulich A, Yeager M, Cozen W, Hoar Zahm S, Chanock SJ, Rothman N, Hartge P . Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte development . Cancer Epidemiol. Biomarkers Prev. . 18 . 4 . 1259–70 . 2009 . 19336552 . 2716008 . 10.1158/1055-9965.EPI-08-1037 .
• Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR . Common genetic variants in candidate genes and risk of familial lymphoid malignancies . Br. J. Haematol. . 146 . 4 . 418–23 . 2009 . 19573080 . 2890251 . 10.1111/j.1365-2141.2009.07790.x .
• Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q . Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity . Occup Environ Med . 66 . 12 . 848–53 . 2009 . 19773279 . 2928224 . 10.1136/oem.2008.044024 .
• Litvinov IV, Zhou Y, Kupper TS, Sasseville D . Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma . Leuk. Lymphoma . 54 . 3 . 653–4 . 2013 . 22856870 . 10.3109/10428194.2012.717695 . 46257094 .

Notes and References

1. Web site: BCL7A BAF chromatin remodeling complex subunit BCL7A [Homo sapiens (human) ]]. 2019-04-28.
2. Baliñas-Gavira . Carlos . Rodríguez . María I. . Andrades . Alvaro . Cuadros . Marta . Álvarez-Pérez . Juan Carlos . Álvarez-Prado . Ángel F. . de Yébenes . Virginia G. . Sánchez-Hernández . Sabina . Fernández-Vigo . Elvira . Muñoz . Javier . Martín . Francisco . Ramiro . Almudena R. . Martínez-Climent . José A. . Medina . Pedro P. . October 2020 . Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL . Leukemia . en . 34 . 10 . 2722–2735 . 10.1038/s41375-020-0919-5 . 32576963 . 219989509 . 0887-6924.
3. van Doorn . Remco . Zoutman . Willem H. . Dijkman . Remco . de Menezes . Renee X. . Commandeur . Suzan . Mulder . Aat A. . van der Velden . Pieter A. . Vermeer . Maarten H. . Willemze . Rein . Yan . Pearlly S. . Huang . Tim H. . Tensen . Cornelis P. . 2005-06-10 . Epigenetic Profiling of Cutaneous T-Cell Lymphoma: Promoter Hypermethylation of Multiple Tumor Suppressor Genes Including BCL7a, PTPRG, and p73 . Journal of Clinical Oncology . en . 23 . 17 . 3886–3896 . 10.1200/JCO.2005.11.353 . 15897551 . 0732-183X.
4. Patiño-Mercau . Juan Rodrigo . Baliñas-Gavira . Carlos . Andrades . Alvaro . Benitez-Cantos . Maria S. . Rot . Ana Ercegovič . Rodriguez . Maria Isabel . Álvarez-Pérez . Juan Carlos . Cuadros . Marta . Medina . Pedro P. . 2023-03-20 . BCL7A is silenced by hypermethylation to promote acute myeloid leukemia . Biomarker Research . en . 11 . 1 . 32 . 10.1186/s40364-023-00472-x . free . 2050-7771 . 10026484 . 36941700.