Brain-specific angiogenesis inhibitor 3 explained

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.^{[1] [2]}

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.^[3]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.^[4] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Research . 9 . 3 . 99–106 . June 2002 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–39 . February 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors . Genomics . 84 . 1 . 23–33 . July 2004 . 15203201 . 10.1016/j.ygeno.2003.12.004 .

Notes and References

1. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T . Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) . Cytogenetics and Cell Genetics . 79 . 1–2 . 103–108 . Apr 1998 . 9533023 . 10.1159/000134693 .
2. Web site: Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3.
3. Lanoue V, Usardi A, Sigoillot SM, Talleur M, Iyer K, Mariani J, Isope P, Vodjdani G, Heintz N, Selimi F . The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons . Molecular Psychiatry . 18 . 8 . 943–950 . August 2013 . 23628982 . 3730300 . 10.1038/mp.2013.46 .
4. Bolliger MF, Martinelli DC, Südhof TC . The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins . Proceedings of the National Academy of Sciences of the United States of America . 108 . 6 . 2534–2539 . February 2011 . 21262840 . 10.1073/pnas.1019577108 . 3038708 . 2011PNAS..108.2534B . free .