BACH1 explained

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.^{[1] [2] [3]}

Function

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip_maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.^[3]

See also

• Small Maf

Further reading

• Ozono R . New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway . Current Pharmaceutical Biotechnology . 7 . 2 . 87–93 . Apr 2006 . 16724942 . 10.2174/138920106776597630 .
• Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K . Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site . Molecular and Cellular Biology . 16 . 11 . 6083–95 . Nov 1996 . 8887638 . 231611 . 10.1128/mcb.16.11.6083 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, Hayashi N, Yamamoto M, Igarashi K . A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain . Molecular and Cellular Biology . 20 . 5 . 1733–46 . Mar 2000 . 10669750 . 85356 . 10.1128/MCB.20.5.1733-1746.2000 .
• Kanezaki R, Toki T, Yokoyama M, Yomogida K, Sugiyama K, Yamamoto M, Igarashi K, Ito E . Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform . The Journal of Biological Chemistry . 276 . 10 . 7278–84 . Mar 2001 . 11069897 . 10.1074/jbc.M004227200 . free .
• Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DM . BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function . Cell . 105 . 1 . 149–60 . Apr 2001 . 11301010 . 10.1016/S0092-8674(01)00304-X . 15966253 . free .
• Kitamuro T, Takahashi K, Ogawa K, Udono-Fujimori R, Takeda K, Furuyama K, Nakayama M, Sun J, Fujita H, Hida W, Hattori T, Shirato K, Igarashi K, Shibahara S . Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells . The Journal of Biological Chemistry . 278 . 11 . 9125–33 . Mar 2003 . 12511571 . 10.1074/jbc.M209939200 . free .
• Suzuki H, Tashiro S, Sun J, Doi H, Satomi S, Igarashi K . Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene . The Journal of Biological Chemistry . 278 . 49 . 49246–53 . Dec 2003 . 14504288 . 10.1074/jbc.M306764200 . free .
• Tahara T, Sun J, Nakanishi K, Yamamoto M, Mori H, Saito T, Fujita H, Igarashi K, Taketani S . Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells . The Journal of Biological Chemistry . 279 . 7 . 5480–7 . Feb 2004 . 14660636 . 10.1074/jbc.M302733200 . free .
• Book: Shim KS, Ferrando-Miguel R, Lubec G . Advances in Down Syndrome Research . Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease . Journal of Neural Transmission. Supplementum . 67. 67 . 39–49 . 15068237 . 10.1007/978-3-7091-6721-2_3 . Journal of Neural Transmission Supplement 67 . 2003 . 978-3-211-40776-9 .
• Book: Ferrando-Miguel R, Cheon MS, Yang JW, Lubec G . Overexpression of transcription factor BACH1 in fetal Down Syndrome brain . Advances in Down Syndrome Research . Journal of Neural Transmission. Supplementum . 67. 67 . 193–205 . 15068251 . 10.1007/978-3-7091-6721-2_17 . Journal of Neural Transmission Supplement 67 . 2003 . 978-3-211-40776-9 .
• Suzuki H, Tashiro S, Hira S, Sun J, Yamazaki C, Zenke Y, Ikeda-Saito M, Yoshida M, Igarashi K . Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 . The EMBO Journal . 23 . 13 . 2544–53 . Jul 2004 . 15175654 . 449764 . 10.1038/sj.emboj.7600248 .
• Tahara T, Sun J, Igarashi K, Taketani S . Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells . Biochemical and Biophysical Research Communications . 324 . 1 . 77–85 . Nov 2004 . 15464985 . 10.1016/j.bbrc.2004.09.022 . 2019-07-11 . 2021-04-20 . https://web.archive.org/web/20210420070028/https://ir.lib.hiroshima-u.ac.jp/files/public/2/21534/20141016141157698753/BBRC_324_77.pdf . dead .
• Shan Y, Lambrecht RW, Ghaziani T, Donohue SE, Bonkovsky HL . Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS . The Journal of Biological Chemistry . 279 . 50 . 51769–74 . Dec 2004 . 15465821 . 10.1074/jbc.M409463200 . free .
• Toki T, Katsuoka F, Kanezaki R, Xu G, Kurotaki H, Sun J, Kamio T, Watanabe S, Tandai S, Terui K, Yagihashi S, Komatsu N, Igarashi K, Yamamoto M, Ito E . Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment . Blood . 105 . 8 . 3100–8 . Apr 2005 . 15613547 . 10.1182/blood-2004-07-2826 . free .

Notes and References

1. Blouin JL, Duriaux Saïl G, Guipponi M, Rossier C, Pappasavas MP, Antonarakis SE . Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1 . Human Genetics . 102 . 3 . 282–8 . Mar 1998 . 9544839 . 10.1007/s004390050692 . 9494442 .
2. Ohira M, Seki N, Nagase T, Ishikawa K, Nomura N, Ohara O . Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1 . Genomics . 47 . 2 . 300–6 . Jan 1998 . 9479503 . 10.1006/geno.1997.5080 .
3. Web site: Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1.