| August Michaelis | |
| Birth Date: | 26 December 1847 |
| Birth Place: | Bierbergen (now part of Hohenhameln), Germany |
| Nationality: | German |
| Death Place: | Rostock, German Empire |
| Work Institution: | University of Karlsruhe University of Aachen University of Rostock |
| Doctoral Advisor: | Johann Georg Anton Geuther |
| Known For: | Michaelis–Arbuzov reaction Michaelis–Becker reaction |
August Michaelis (26 December 1847 – 31 January 1916) was a German chemist and discovered the Michaelis–Arbuzov reaction.
Michaelis studied at the University of Göttingen and University of Jena and became professor for chemistry at University of Karlsruhe in 1876, at the University of Aachen in 1880, and at the University of Rostock in 1890.