Arylsulfatase Explained

Arylsulfatase (EC 3.1.6.1, sulfatase, nitrocatechol sulfatase, phenolsulfatase, phenylsulfatase, p-nitrophenyl sulfatase, arylsulfohydrolase, 4-methylumbelliferyl sulfatase, estrogen sulfatase) is a type of sulfatase enzyme with systematic name aryl-sulfate sulfohydrolase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

an aryl sulfate + H₂O

a phenol + sulfate

It catalyses an analogous reaction for sulfonated hexoses. Types include:

• Arylsulfatase A (also known as "cerebroside-sulfatase")
• Arylsulfatase B (also known as "N-acetylgalactosamine-4-sulfatase")
• Steroid sulfatase (formerly known as "arylsulfatase C")
• ARSC2
• ARSD
• ARSF
• ARSG
• ARSH
• ARSI
• ARSJ
• ARSK
• ARSL (formerly known as "arylsulfatase E", "ARSE")

See also

• Aryl

Notes and References

1. Dodgson KS, Spencer B, Williams K . Studies on sulphatases. 13. The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metalcaligenes . The Biochemical Journal . 64 . 2 . 216–21 . October 1956 . 13363831 . 1199721 .
2. Roy AB . The synthesis and hydrolysis of sulfate esters . Advances in Enzymology and Related Subjects of Biochemistry . 22 . 205–35 . 1960 . 13744184 .
3. Roy AB . Sulphatases, lysosomes and disease . The Australian Journal of Experimental Biology and Medical Science . 54 . 2 . 111–35 . April 1976 . 13772 . 10.1038/icb.1976.13 .
4. Webb EC, Morrow PF . The activation of an arysulphatase from ox liver by chloride and other anions . The Biochemical Journal . 73 . 1 . 7–15 . September 1959 . 13843260 . 1197004 .