Arylalkanolamines (ArROHNR2) are a class of medicinal molecules that are structurally related to one another in certain respects.
Detailed understanding of their structure-activity relationship is expected to aid in drug discovery.
| Group | 1/2/3° OH | Α/Β/Γ/Δ | Α/Β/Γ/Δ | N | Type of Pharmacology | - | PRC025 | 3-OH-2-BN-A | 2° | γ-aminoalcohol | β | NHMe2 | SN(D)RI | - | PP-3-A | 2° | " | α,β | NHMe | NS(D)RI | - | Pridinol | " | 3° | " | NC5H10 | Anticholinergic (NMDA?) | - | Trihexyphenidyl (aka Benzhexol) | " | " | " | " | " | - | Biperiden | " | " | " | " | " | - | BDPC | cyclohexanol | 3° | δ-aminoalcohol | γ,δ | NMe2 | μ/delta-opioid agonist | - | " | " | 3 | α-arylalcohol | " | μ-opioid agonist(prodrug, M1SNRI | - | " | " | 2 | β-arylalcohol | " | SNRI | - | " | 2° | 3 | γ-arylalcohol | " | μ-opioid mixed ant/agonist | - | PP-2-A | 2° | 2 | NH2 | - | " | " | " | " | - | " | " | β-aminoalcohol | NHMe | - | " | " | " | " | - | " | " | " | " | - | ArE-2-A | " | " | " | - | " | " | " | NH2 | neurotransmitter | - | " | " | " | " | α1 agonist | - | " | " | " | " | α1 agonist | - | " | " | " | NH(t-Bu) | β-agonist | - | " | " | " | " | " | - | 3° | δ | 4,4 | piper | DA antagonist | - | Loperamide(Imodium AD) | " | " | " | " | " | μ-opioid agonist. |