Arsenite-transporting ATPase explained

In enzymology, an arsenite-transporting ATPase is an enzyme that catalyzes the chemical reaction

ATP + H₂O + arsenitein

ADP + phosphate + arseniteout

The 3 substrates of this enzyme are ATP, H₂O, and arsenite, whereas its 3 products are ADP, phosphate, and arsenite.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting).

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and .

See also

• Arsenite-Antimonite efflux

References

• Silver S, Misra TK, Laddaga RA . 1989 . DNA sequence analysis of bacterial toxic heavy metal resistances . . 21 . 145 - 63 . 2484581 . 10.1007/BF02917247 . 19834681 .
• Rosen BP, Weigel U, Monticello RA, Edwards BP . 1991 . Molecular analysis of an anion pump: purification of the ArsC protein . . 284 . 381 - 5 . 1703401 . 10.1016/0003-9861(91)90312-7 . 2 .
• Rosen BP, Weigel U, Monticello RA, Edwards BP . 1991 . Molecular analysis of an anion pump: purification of the ArsC protein . . 284 . 381 - 5 . 1703401 . 10.1016/0003-9861(91)90312-7 . 2 .
• Zhou T, Rosen BP, Gatti DL . Crystallization and preliminary x-ray analysis of the catalytic subunit of the ATP-dependent arsenite pump encoded by the Escherichia coli plasmid R773 . . 1999. 55 . 921 - 4 . 10089335 . 10.1107/S0907444999000256 . Pt 4 .