| State: | AR |
| Type: | AR |
| Route: | 159 |
| Map Custom: | yes |
| Map Notes: | Segments of AR 159 in red |
| Maint: | AHTD |
| Previous Type: | AR |
| Previous Route: | 158 |
| Next Type: | AR |
| Next Route: | 160 |
Highway 159 (AR 159, Ark. 159, and Hwy. 159) is a designation for eight state highways in Chicot and Desha Counties.
| State: | AR |
| Route: | 159 |
| Type: | AR |
| Length Mi: | 5.48 |
| Length Round: | 2 |
| Location: | Eudora–Lake Village |
Between Lake Village and Eudora, Arkansas, Highway 159 follows the original 1926 alignment of U.S. 65
| State: | AR |
| Route: | 159 |
| Type: | AR |
| Length Mi: | 4.92 |
| Length Round: | 2 |
| Location: | Halley–Trippe Junction |
| State: | AR |
| Route: | 159 |
| Type: | AR |
| Length Mi: | 0.80 |
| Length Round: | 2 |
| Location: | Downtown McGehee |
| State: | AR |
| Route: | 159 |
| Type: | AR |
| Length Mi: | 4.41 |
| Length Round: | 2 |
| Location: | AR 138–Omega |
| State: | AR |
| Route: | 159 |
| Type: | AR |
| Length Mi: | 1.74 |
| Length Round: | 2 |
| Location: | Dumas–Mitchellville |