Arcarine Explained

Class:Selective androgen receptor modulator
Synonyms:ORM-11984

Arcarine (ORM-11984) is a selective androgen receptor modulator (SARM) developed by Orion Corporation, a Finnish pharmaceutical company.[1] [2] [3] It belongs to a class of drugs designed to have tissue-selective androgenic effects, potentially offering the benefits of androgens while minimizing unwanted side effects. Arcarine was investigated for the treatment of various conditions, including benign prostatic hyperplasia, hypogonadism, and osteoporosis.[4] [5] The compound reached Phase I clinical trials before development was discontinued. Like other SARMs, Arcarine was developed to potentially provide anabolic effects in muscle and bone tissue while having reduced androgenic effects in other tissues, such as the prostate.

Notes and References

  1. Aro HT, Kulkova J, Moritz N, Kähkönen E, Mattila RH . Local delivery of a selective androgen receptor modulator failed as an anabolic agent in a rat bone marrow ablation model . Acta Orthopaedica . 86 . 6 . 751–9 . 2015 . 26198725 . 4750778 . 10.3109/17453674.2015.1074840 . 1 November 2024 .
  2. Web site: Research programme: selective androgen receptor modulators (Alternative Names: Arcarine; ORM-11984) . AdisInsight . 4 November 2017 . 17 October 2024.
  3. Web site: Delving into the Latest Updates on Arcarine with Synapse . Synapse . 13 October 2024 . 17 October 2024.
  4. Web site: Arcarine . Synapse . PatSnap . 2024-01-14 . 2024-01-14 . https://web.archive.org/web/20240114011909/https://synapse.patsnap.com/drug/3c0a1cb1cbc14552b622c39a85ef56fd . live .
  5. Xie Y, Tian Y, Zhang Y, Zhang Z, Chen R, Li M, Tang J, Bian J, Li Z, Xu X . Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998-2021) . European Journal of Medicinal Chemistry . 230 . 114119 . February 2022 . 35063736 . 10.1016/j.ejmech.2022.114119 .

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