Andrej Janež Explained

Andrej Janež is a Slovenian diabetologist and diabetes researcher. Janež is the Head of Department of Endocrinology, Diabetes and Metabolic Disease at University Medical Centre Ljubljana, Assistant Professor for Internal Medicine at the Medical University Ljubljana, Chairman of the Advances in Diabetes and Insulin Therapy conference,^[1] member of the advisory board for peroral antidiabetic therapy in Servier Pharma, member for Slovenia in the Diabetes Education Study Group at European Association for the Study of Diabetes, and member of the European advisory board for continuous glucose monitoring system in development for Lifescan.

Janež authored numerous articles^[2] on diabetology and indexed by Science Citation Index, co-edited a clinical manual on continuous subcutaneous insulin infusion therapy, or insulin pump treatment. The latter is also the best known area of Janež's scientific work, as he introduced insulin pump treatment to India, Turkey, China, Slovenia, and several other countries, where he also led the effort of educating teams of diabetologists required for a continuous application of the technique.

Education

• MD, 1996, School of Medicine, University of Ljubljana
• MS, 1998, School of Medicine, University of Ljubljana with thesis "Effects of chromium on blood pressure in humans"
• PhD, 2000, Diabetology School of Medicine, University of California, San Diego, with thesis Mechanism of glucose transport in insulin resistant 3T3-L1 adipocytes
• Post doctoral, 2005, Joslin Diabetes Clinic, Boston, study on insulin pump therapy in type 1 diabetic patients

Work

Upon his return from the U.S., Janež introduced the insulin pump method into clinical practice of treating adult patients with type 1 diabetes in Slovenia. Together with his colleagues from the Department of Endocrinology, Diabetes, and Metabolic Disease at University Medical Centre Ljubljana, Janež co-authored the algorithm used in insulin pump treatment, as well as tutored virtually all Slovenian diabetologists in usage of both insulin pump and glucose sensor. Janež also wrote all of the literature on subjects of functional insulin therapy and insulin pump in Slovenia, with its audiences ranging from diabetologists to patients. In 2008, he established a new unit for functional insulin therapy within the University Medical Centre.

Janež also led the effort of forming international standards for interpretation of results obtained with glucose sensor, publishing and presenting these on several international diabetes-related symposiums.

Coupled with his previous work in the field of functional insulin therapy and its pilot implementation in Slovenia, Janež went on to introduce this approach to diabetes treatment in other countries.

Publications

• Pratley . Richard E . Nauck . Michael . Bailey . Timothy . Montanya . Eduard . Cuddihy . Robert . Filetti . Sebastiano . Thomsen . Anne Bloch . Søndergaard . Rie Elvang . Davies . Melanie . Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial . The Lancet . 375 . 1447–56 . 2010 . 10.1016/S0140-6736(10)60307-8 . 20417856 . 9724 . 3291387 .
• Buse . John B . Rosenstock . Julio . Sesti . Giorgio . Schmidt . Wolfgang E . Montanya . Eduard . Brett . Jason H . Zychma . Marcin . Blonde . Lawrence . Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) . The Lancet . 374 . 39–47 . 2009 . 10.1016/S0140-6736(09)60659-0 . 9683 . 19515413. 25135640 .
• Jensterle . M. . Sebestjen . M. . Janez . A. . Prezelj . J. . Kocjan . T. . Keber . I. . Pfeifer . M. . Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome . European Journal of Endocrinology . 159 . 4 . 399–406 . 2008 . 18653546 . 10.1530/EJE-08-0507. free .
• Jensterle . M . Weber . M . Pfeifer . M . Prezelj . J . Pfutzner . A . Janez . A . Assessment of insulin resistance in young women with polycystic ovary syndrome . International Journal of Gynecology & Obstetrics . 102 . 137–40 . 2008 . 10.1016/j.ijgo.2008.03.017 . 18504045 . 2. 13513083 .
• Jensterle . M. . Janez . A. . Mlinar . B. . Marc . J. . Prezelj . J. . Pfeifer . M. . Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome . European Journal of Endocrinology . 158 . 6 . 793–801 . 2008 . 18322300 . 10.1530/EJE-07-0857. free .
• Jensterle . Mojca . Janez . Andrej . Vrtovec . Bojan . Meden-Vrtovec . Helena . Pfeifer . Marija . Prezelj . Janez . Kocjan . Tomaz . Decreased Androgen Levels and Improved Menstrual Pattern after Angiotensin II Receptor Antagonist Telmisartan Treatment in Four Hypertensive Patients with Polycystic Ovary Syndrome: Case Series . Croatian Medical Journal . 48 . 6 . 864–70 . 2007 . 18074422 . 2213810 . 10.3325/cmj.2007.6.864.
• Silič . Anja . Janež . Andrej . Tomažič . Janez . Karner . Primož . Vidmar . Ludvik . Sharma . Prem . Matičič . Mojca . Effect of Rosiglitazone and Metformin on Insulin Resistance in Patients Infected with Human Immunodeficiency Virus Receiving Highly Active Antiretroviral Therapy Containing Protease Inhibitor: Randomized Prospective Controlled Clinical Trial . Croatian Medical Journal . 48 . 6 . 791–9 . 2007 . 18074413 . 2213797 . 10.3325/cmj.2007.6.791.
• Steiner . Charles A. . Janez . Andrej . Jensterle . Mojca . Reisinger . Katrin . Forst . Thomas . Pfützner . Andreas . Impact of treatment with rosiglitazone or metformin on biomarkers for insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome . Journal of Diabetes Science and Technology . 1 . 2 . 211–7 . 2007 . 19888409 . 2771474 . 10.1177/193229680700100212.
• Mlinar . B . Marc . J . Janez . A . Pfeifer . M . Molecular mechanisms of insulin resistance and associated diseases . Clinica Chimica Acta . 375 . 1–2 . 20–35 . 2007 . 16956601 . 10.1016/j.cca.2006.07.005.
• Tomazic . J . Karner . P . Vidmar . L . Maticic . M . Sharma . PM . Janez . A . Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART . Acta Dermatovenerologica Alpina, Pannonica et Adriatica . 14 . 3 . 99–105 . 2005 . 16200335.
• Tomažič . Janez . Silič . Anja . Karner . Primož . Vidmar . Ludvik . Matičič . Mojca . Poljak . Mario . Ihan . Alojz . Janež . Andrej . Lipodystrophy and metabolic abnormalities in Slovenian HIV-infected patients . Wiener Klinische Wochenschrift . 116 . 21–22 . 755–9 . 2004 . 15628647 . 10.1007/s00508-004-0268-9. 24715784 .
• Tomazic . M. . Janez . A. . Sketelj . A. . Kocijancic . A. . Eckel . J. . Sharma . P. . Comparison of alterations in insulin signalling pathway in adipocytes from type II diabetic pregnant women and women with gestational diabetes mellitus . Diabetologia . 45 . 4 . 502–8 . 2002 . 12032625 . 10.1007/s00125-002-0791-z. free .
• Hevener . A. . Reichart . D. . Janez . A. . Olefsky . J. . Female Rats Do Not Exhibit Free Fatty Acid-Induced Insulin Resistance . Diabetes . 51 . 6 . 1907–12 . 2002 . 12031980 . 10.2337/diabetes.51.6.1907. free .
• Hevener . A. L. . Reichart . D. . Janez . A. . Olefsky . J. . Thiazolidinedione Treatment Prevents Free Fatty Acid-Induced Insulin Resistance in Male Wistar Rats . Diabetes . 50 . 10 . 2316–22 . 2001 . 11574414 . 10.2337/diabetes.50.10.2316. free .
• Ravnik-Oblak . M . Janez . A . Kocijanicic . A . Insulinoma induced hypoglycemia in a type 2 diabetic patient . Wiener Klinische Wochenschrift . 113 . 9 . 339–41 . 2001 . 11388080.
• Janez . A. . The osmotic shock-induced glucose transport pathway in 3T3-L1 adipocytes is mediated by Gab-1 and requires Gab-1 associated phosphatidylinositol 3-kinase activity for full activation . Journal of Biological Chemistry . 26870–6 . 2000 . 10.1074/jbc.M001654200 . 10842168 . 275. 35 . free .
• Janez . A. . Worrall . DS . Olefsky . JM . Insulin-Mediated Cellular Insulin Resistance Decreases Osmotic Shock-Induced Glucose Transport in 3T3-L1 Adipocytes . Endocrinology . 141 . 12 . 4657–63 . 2000 . 11108280 . 10.1210/endo.141.12.7801. free .

External links

• 3rd International Conference on Advances in Diabetes and Insulin Therapy

Notes and References

1. Web site: ADIT 2011 Priliminary list of Faculty . 2011-02-28 . https://web.archive.org/web/20101018053912/http://www.adit-conf.org/faculty.html . 2010-10-18 . dead .
2. http://cobiss6.izum.si/scripts/cobiss?ukaz=CLNG&lani=en&id=1224301685270796# Web site: Osnovno iskanje :: COBISS+ . 2011-02-24 . https://web.archive.org/web/20160826020100/http://cobiss6.izum.si/scripts/cobiss?ukaz=CLNG&lani=en&id=1224301685270796 . 2016-08-26 . bot: unknown . Search in the Slovenian Library Database