Amlodipine/valsartan explained

Amlodipine/valsartan, sold under the brand name Exforge among others, is a blood pressure lowering combination drug. It contains amlodipine, as the besilate, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin II receptor antagonist.^[6] This combination is usually well tolerated and effective for the reduction of blood pressure.^[7]

The combination was approved for medical use in the European Union in January 2007, and in the United States in June 2007.^[8]

The combination is also available with hydrochlorothiazide.^{[9] [10]} It was approved for medical use in the United States in April 2009,^[11] and in the European Union in November 2009.^{[12] [13] [14]}

Notes and References

1. Web site: Amlodipine / valsartan (Exforge) Use During Pregnancy . Drugs.com . 11 July 2019 . 13 February 2020.
2. Web site: Exforge- amlodipine besylate and valsartan tablet, film coated . DailyMed . 12 June 2019 . 12 February 2020.
3. Web site: Exforge EPAR . European Medicines Agency (EMA) . 17 January 2007 . 26 August 2024.
4. Web site: Copalia EPAR . European Medicines Agency (EMA) . 16 January 2007 . 26 August 2024.
5. Web site: Dafiro EPAR . European Medicines Agency (EMA) . 16 January 2007 . 26 August 2024.
6. Web site: Valsartan Monograph for Professionals . Drugs.com . American Society of Health-System Pharmacists . 3 March 2019.
7. Eckert S, Freytag SB, Müller A, Klebs SH . Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors . Blood Pressure . 22 . sup1 . 11–21 . September 2013 . 23713686 . 10.3109/08037051.2013.793891 . 25814898 .
8. Web site: Drug Approval Package: Exforge (amlodipine and valsartan) NDA #021990 . U.S. Food and Drug Administration (FDA) . 3 October 2008 . 19 September 2021.
9. Web site: Exforge HCT- amlodipine valsartan and hydrochlorothiazide tablet, film coated . DailyMed . 12 February 2020.
10. Web site: Amlodipine, Valsartan, and Hydrochlorothiazide . Drugs.com .
11. Web site: Drug Approval Package: Exforge HCT (Amlodipine, Valsartan, Hydrochlorothiazide) Tablets NDA #022314 . U.S. Food and Drug Administration (FDA) . 2 September 2009 . 19 September 2021 .
12. Web site: Exforge HCT EPAR . European Medicines Agency (EMA) . 16 October 2009 . 26 August 2024.
13. Web site: Copalia HCT EPAR . European Medicines Agency (EMA) . 4 November 2009 . 26 August 2024.
14. Web site: Dafiro HCT EPAR . European Medicines Agency (EMA) . 4 November 2009 . 26 August 2024.