Amidephrine Explained

Amidephrine, or amidefrine, sold under the brand name Fentrinol among others, is a selective α1-adrenergic receptor agonist which is described as an adrenergic or sympathomimetic, vasoconstrictor, and topical nasal decongestant used to treat allergic rhinitis.[1] [2] [3] [4] [5] It is used as the mesylate salt, which has the generic names amidefrine mesilate and amidephrine mesylate . The drug is a substituted phenethylamine derivative and is also known as 3-methylsulfonamidyl-β-hydroxy-N-methylphenethylamine.[6] As of 2000, it remained marketed only in Austria.

Notes and References

  1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer US . 2014 . 978-1-4757-2085-3 . 2024-08-31 . 40.
  2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms . Springer Netherlands . 2012 . 978-94-011-4439-1 . 2024-08-31 . 13.
  3. Book: Schweizerischer Apotheker-Verein . Index Nominum 2000: International Drug Directory . Medpharm Scientific Publishers . 2000 . 978-3-88763-075-1 . 2024-08-31 . 39.
  4. Web site: Amidephrine: Uses, Interactions, Mechanism of Action . DrugBank Online . 24 February 2021 . 31 August 2024.
  5. MacLean MR, Thomson M, Hiley CR . Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine . British Journal of Pharmacology . 97 . 2 . 419–432 . June 1989 . 2569342 . 1854522 . 10.1111/j.1476-5381.1989.tb11969.x .
  6. Web site: Amidephrine . PubChem . U.S. National Library of Medicine . 31 August 2024.

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