Alpha-bisabolene synthase explained
| α-isabolene synthase |
| Ec Number: | 4.2.3.38 |
α-Bisabolene synthase (EC 4.2.3.38, bisabolene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((E)-α-bisabolene-forming).[1]
This enzyme catalyses the following chemical reaction:
(2E,6E)-farnesyl diphosphate
(
E)-α-bisabolene + diphosphate
This synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group.
Notes and References
- Bohlmann J, Crock J, Jetter R, Croteau R . Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-alpha-bisabolene synthase from grand fir (Abies grandis) . Proceedings of the National Academy of Sciences of the United States of America . 95 . 12 . 6756–61 . June 1998 . 9618485 . 22624 . 10.1073/pnas.95.12.6756 . 1998PNAS...95.6756B . free .
