| Afon Gwili | |
| Pushpin Map: | Wales |
| Subdivision Type1: | Country |
| Subdivision Name1: | Wales |
| Subdivision Type2: | County |
| Subdivision Name2: | Carmarthenshire |
| Source1 Location: | Near Cross Hands |
| Mouth: | River Loughor |
| Mouth Location: | Near Pontarddulais |
| Mouth Coordinates: | 51.7093°N -4.0521°W |
The Afon Gwili is a right-bank tributary of the River Loughor in the east of Carmarthenshire, South Wales. It rises near Cross Hands before flowing in a generally southerly direction past the small village of Cwmgwili to join with the Loughor beyond Hendy near Pontarddulais.[1]