Abafungin Explained

Abafungin (INN) is a broad-spectrum arylguanidines-class antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.[1]

Abasol is a topical cream formulation of abafungin by York Pharma.[2]

History

Abafungin was first synthesized at Bayer AG, Leverkusen, Germany. A study of H2-antagonists related to famotidine, resulted in the discovery of its antifungal properties.[3]

Its development seems to have been discontinued in 2009.[4]

Mechanism of action

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.[3]

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.[5]

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[6]

Notes and References

  1. Borelli C, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC . Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi . Chemotherapy . 54 . 4 . 245–259 . 2008 . 18587237 . 2818358 . 10.1159/000142334 .
  2. Web site: Regulatory Update – Abasol . York Pharma . https://web.archive.org/web/20070927102715/http://www.yorkpharma.com/media/YRK-Update_Abasol_061002-FN.pdf . September 27, 2007 .
  3. Borelli C, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC . Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi . Chemotherapy . 54 . 4 . 245–259 . August 2008 . 18587237 . 2818358 . 10.1159/000142334 .
  4. Web site: Abafungin. AdisInsight. 5 May 2021.
  5. Ruiz-Ortega M, González S, Serón D, Condom E, Bustos C, Largo R, González E, Ortiz A, Egido J . ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis . Kidney International . 48 . 6 . 1778–1791 . December 1995 . 8587237 . 10.1038/ki.1995.476 . free .
  6. Book: Ginter-Hanselmayer G . March 2009. Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten . Working documents for the 42nd scientific training event for pharmacists: Infectious diseases . de . Österreichische Apothekerkammer (Austrian Chamber of Pharmacists) . 103.

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