ATP6V1G1 explained

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.^{[1] [2]}

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized.

Further reading

• Finbow ME, Harrison MA . The vacuolar H+-ATPase: a universal proton pump of eukaryotes . Biochem. J. . 324 . Pt 3. 697–712 . 1997 . 9210392 . 10.1042/bj3240697. 1218484 .
• Stevens TH, Forgac M . Structure, function and regulation of the vacuolar (H+)-ATPase . Annu. Rev. Cell Dev. Biol. . 13 . 779–808 . 1998 . 9442887 . 10.1146/annurev.cellbio.13.1.779 .
• Nelson N, Harvey WR . Vacuolar and plasma membrane proton-adenosinetriphosphatases . Physiol. Rev. . 79 . 2 . 361–85 . 1999 . 10221984 . 10.1152/physrev.1999.79.2.361. 1477911 .
• Forgac M . Structure and properties of the vacuolar (H+)-ATPases . J. Biol. Chem. . 274 . 19 . 12951–4 . 1999 . 10224039 . 10.1074/jbc.274.19.12951 . free .
• Kane PM . Introduction: V-ATPases 1992-1998 . J. Bioenerg. Biomembr. . 31 . 1 . 3–5 . 1999 . 10340843 . 10.1023/A:1001884227654 .
• Wieczorek H, Brown D, Grinstein S . Animal plasma membrane energization by proton-motive V-ATPases . BioEssays . 21 . 8 . 637–48 . 1999 . 10440860 . 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W . 23505139 . etal.
• Nishi T, Forgac M . The vacuolar (H+)-ATPases--nature's most versatile proton pumps . Nat. Rev. Mol. Cell Biol. . 3 . 2 . 94–103 . 2002 . 11836511 . 10.1038/nrm729 . 21122465 .
• Kawasaki-Nishi S, Nishi T, Forgac M . Proton translocation driven by ATP hydrolysis in V-ATPases . FEBS Lett. . 545 . 1 . 76–85 . 2003 . 12788495 . 10.1016/S0014-5793(03)00396-X . 10507213 .
• Morel N . Neurotransmitter release: the dark side of the vacuolar-H+ATPase . Biol. Cell . 95 . 7 . 453–7 . 2004 . 14597263 . 10.1016/S0248-4900(03)00075-3 . 17519696 . free .
• Zhang QH, Ye M, Wu XY . Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . etal.
• Smith AN, Borthwick KJ, Karet FE . Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis . Gene . 297 . 1–2 . 169–77 . 2003 . 12384298 . 10.1016/S0378-1119(02)00884-3 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .

Notes and References

1. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z . Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning . Proc Natl Acad Sci U S A . 95 . 14 . 8175–80 . Aug 1998 . 9653160 . 20949 . 10.1073/pnas.95.14.8175 . 1998PNAS...95.8175M . free .
2. Web site: Entrez Gene: ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1.