ATP1B1 explained

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.^[1]

The protein encoded by this gene belongs to the family of Na⁺/K⁺ and H⁺/K⁺ ATPases beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Lingrel JB, Orlowski J, Shull MM, Price EM . Molecular genetics of Na,K-ATPase . Prog. Nucleic Acid Res. Mol. Biol. . 38 . 37–89 . 1990 . 2158121 . 10.1016/S0079-6603(08)60708-4 . Progress in Nucleic Acid Research and Molecular Biology . 978-0-12-540038-1 .
• Oakey RJ, Watson ML, Seldin MF . Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA . Hum. Mol. Genet. . 1 . 8 . 613–20 . 1993 . 1301170 . 10.1093/hmg/1.8.613 .
• Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R . Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression . J. Biol. Chem. . 264 . 8 . 4613–8 . 1989 . 10.1016/S0021-9258(18)83787-5 . 2538450 . free .
• ((Ushkaryov YuA)), Monastyrskaya GS, Broude NE . Human Na⁺,K⁺-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene . FEBS Lett. . 257 . 2 . 439–42 . 1990 . 2555225 . 10.1016/0014-5793(89)81591-1 . 13623201 . etal.
• Lane LK, Shull MM, Whitmer KR, Lingrel JB . Characterization of two genes for the human Na,K-ATPase beta subunit . Genomics . 5 . 3 . 445–53 . 1990 . 2559024 . 10.1016/0888-7543(89)90008-6 .
• Yang-Feng TL, Schneider JW, Lindgren V . Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes . Genomics . 2 . 2 . 128–38 . 1988 . 2842249 . 10.1016/0888-7543(88)90094-8 . etal.
• Sverdlov ED, Broude NE, Sverdlov VE . Family of Na⁺,K⁺-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism . FEBS Lett. . 221 . 1 . 129–33 . 1987 . 2887455 . 10.1016/0014-5793(87)80366-6 . 32756405 . etal.
• Kawakami K, Nojima H, Ohta T, Nagano K . Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit . Nucleic Acids Res. . 14 . 7 . 2833–44 . 1986 . 3008098 . 10.1093/nar/14.7.2833 . 339706 .
• Coca-Prados M, Fernández-Cabezudo MJ, Sánchez-Torres J . Cell-specific expression of the human Na⁺,K⁺-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium . Invest. Ophthalmol. Vis. Sci. . 36 . 13 . 2717–28 . 1996 . 7499094 . etal.
• Ruiz A, Bhat SP, Bok D . Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium . Gene . 155 . 2 . 179–84 . 1995 . 7536695 . 10.1016/0378-1119(94)00812-7 .
• Mobasheri A, Oukrif D, Dawodu SP . Isoforms of Na⁺, K⁺-ATPase in human prostate; specificity of expression and apical membrane polarization . Histol. Histopathol. . 16 . 1 . 141–54 . 2001 . 11193188 . etal.
• Gamaleĭ IA, ((Polozov IuS)), Aksenov ND . [Cell cycle and formation of active form of oxygen in rodent fibroblasts] . Tsitologiia . 43 . 6 . 602–12 . 2001 . 11534180 . etal.
• Béguin P, Crambert G, Monnet-Tschudi F . FXYD7 is a brain-specific regulator of Na,K-ATPase α1–β isozymes . EMBO J. . 21 . 13 . 3264–73 . 2002 . 12093728 . 10.1093/emboj/cdf330 . 125393 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Zhang H, Li XJ, Martin DB, Aebersold R . Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry . Nat. Biotechnol. . 21 . 6 . 660–6 . 2003 . 12754519 . 10.1038/nbt827 . 581283 .
• Fuller W, Eaton P, Bell JR, Shattock MJ . Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase . FASEB J. . 18 . 1 . 197–9 . 2004 . 14597563 . 10.1096/fj.03-0213fje . free . 41768501 .
• Li J, Codina J, Petroske E . The carboxy terminus of the colonic H⁺, K⁺-ATPase alpha-subunit is required for stable beta subunit assembly and function . Kidney Int. . 65 . 4 . 1301–10 . 2004 . 15086469 . 10.1111/j.1523-1755.2004.00507.x . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Wickham L, Benjannet S, Marcinkiewicz E . Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin . J. Neurochem. . 92 . 1 . 93–102 . 2005 . 15606899 . 10.1111/j.1471-4159.2004.02840.x . etal. free .

Notes and References

1. Web site: Entrez Gene: ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide.