ARMS2 explained

Age-related maculopathy susceptibility protein 2, is a mitochondrial protein that in humans is encoded by the ARMS2 gene.^{[1] [2] [3]}

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Schmidt S, Hauser MA, Scott WK . Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. . Am. J. Hum. Genet. . 78 . 5 . 852–64 . 2006 . 16642439 . 10.1086/503822 . 1474047 . etal.
• Shastry BS . Further support for the common variants in complement factor H (Y402H) and LOC387715 (A69S) genes as major risk factors for the exudative age-related macular degeneration. . Ophthalmologica . 220 . 5 . 291–5 . 2006 . 16954704 . 10.1159/000094617 . 30250011 .
• Conley YP, Jakobsdottir J, Mah T . CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses. . Hum. Mol. Genet. . 15 . 21 . 3206–18 . 2006 . 17000705 . 10.1093/hmg/ddl396 . etal. free .
• Tanimoto S, Tamura H, Ue T . A polymorphism of LOC387715 gene is associated with age-related macular degeneration in the Japanese population. . Neurosci. Lett. . 414 . 1 . 71–4 . 2007 . 17194541 . 10.1016/j.neulet.2006.12.011 . 19228896 . etal.
• Shastry BS . Assessment of the contribution of the LOC387715 gene polymorphism in a family with exudative age-related macular degeneration and heterozygous CFH variant (Y402H). . J. Hum. Genet. . 52 . 4 . 384–7 . 2007 . 17285240 . 10.1007/s10038-007-0120-y . free .
• Ross RJ, Bojanowski CM, Wang JJ . The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. . Invest. Ophthalmol. Vis. Sci. . 48 . 3 . 1128–32 . 2007 . 17325155 . 10.1167/iovs.06-0999 . 1885234 . etal.
• Francis PJ, George S, Schultz DW . The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration. . Hum. Hered. . 63 . 3–4 . 212–8 . 2007 . 17347568 . 10.1159/000100046 . 43821054 . etal.
• Chen D, Langford MP, Duggan C . Expression of recombinant protein encoded by LOC387715 in Escherichia coli. . Protein Expr. Purif. . 54 . 2 . 275–82 . 2007 . 17485225 . 10.1016/j.pep.2007.03.017 . 2780029 . etal.
• Kondo N, Honda S, Ishibashi K . LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population. . Am. J. Ophthalmol. . 144 . 4 . 608–12 . 2007 . 17692272 . 10.1016/j.ajo.2007.06.003 . etal.
• Wiggs JL . Macular degeneration: risk factors for progression. . Arch. Ophthalmol. . 125 . 9 . 1264–5 . 2007 . 17846368 . 10.1001/archopht.125.9.1264 .
• Kanda A, Chen W, Othman M . A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 41 . 16227–32 . 2007 . 17884985 . 10.1073/pnas.0703933104 . 1987388 . etal. free . 2007PNAS..10416227K .
• Brantley MA, Fang AM, King JM . Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab. . Ophthalmology . 114 . 12 . 2168–73 . 2007 . 18054635 . 10.1016/j.ophtha.2007.09.008 . etal.

Notes and References

1. Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB . Susceptibility genes for age-related maculopathy on chromosome 10q26 . Am J Hum Genet . 77 . 3 . 389–407 . Aug 2005 . 16080115 . 1226205 . 10.1086/444437 .
2. Rivera A, Fisher SA, Fritsche LG, Keilhauer CN, Lichtner P, Meitinger T, Weber BH . Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk . Hum Mol Genet . 14 . 21 . 3227–36 . Oct 2005 . 16174643 . 10.1093/hmg/ddi353 . free .
3. Web site: Entrez Gene: ARMS2 age-related maculopathy susceptibility 2.