ARID5B explained

AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.^{[1] [2] [3]}

Alternative names for this gene include Modulator recognition factor 23.

Genomics

The gene is located on the long arm of chromosome 10 (10q21.2) on the 'plus' strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilodaltons respectively.

Clinical importance

Through genome wide association studies (GWAS), some of the single nucleotide polymorphisms (SNPs) located in this gene has been noticed to be significantly associated with susceptibility ^{[4] [5] [6]} as well as treatment outcomes ^[7] of childhood acute lymphoblastic leukaemia in ethnically diverse populations.

Further reading

• Yuan YC, Whitson RH, Liu Q, Itakura K, Chen Y . A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases . Nature Structural Biology . 5 . 11 . 959–64 . Nov 1998 . 9808040 . 10.1038/2934 . 10099806 .
• Whitson RH, Huang T, Itakura K . The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts . Biochemical and Biophysical Research Communications . 258 . 2 . 326–31 . May 1999 . 10329386 . 10.1006/bbrc.1999.0643 .
• Patsialou A, Wilsker D, Moran E . DNA-binding properties of ARID family proteins . Nucleic Acids Research . 33 . 1 . 66–80 . 2005 . 15640446 . 546134 . 10.1093/nar/gki145 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I . Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs . Genome Research . 11 . 8 . 1327–34 . Aug 2001 . 11483573 . 10.1101/gr.168801 . free . 10536/DRO/DU:30121320 . free .
2. Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y . Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA . Biochemistry . 40 . 31 . 9142–50 . Aug 2001 . 11478881 . 10.1021/bi010476a .
3. Web site: Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like).
4. Xu H, Yang W, Perez-Andreu V, Devidas M, Fan Y, Cheng C, Pei D, Scheet P, Burchard EG, Eng C, Huntsman S, Torgerson DG, Dean M, Winick NJ, Martin PL, Camitta BM, Bowman WP, Willman CL, Carroll WL, Mullighan CG, Bhojwani D, Hunger SP, Pui CH, Evans WE, Relling MV, Loh ML, Yang JJ . 6 . Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations . Journal of the National Cancer Institute . 105 . 10 . 733–42 . May 2013 . 23512250 . 10.1093/jnci/djt042 . 3691938.
5. Treviño LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M, Willman C, Neale G, Downing J, Raimondi SC, Pui CH, Evans WE, Relling MV . 6 . Germline genomic variants associated with childhood acute lymphoblastic leukemia . Nature Genetics . 41 . 9 . 1001–5 . September 2009 . 19684603 . 10.1038/ng.432 . 7 . 2762391.
6. Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Tomlinson IP, Taylor M, Greaves M, Houlston RS . 6 . Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia . Nature Genetics . 41 . 9 . 1006–10 . September 2009 . 19684604 . 10.1038/ng.430 . 4915548 .
7. Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, Neale G, Scheet P, Burchard EG, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh M, Evans WE, Pui CH, Hunger SP, Relling MV, Yang JJ . 6 . ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia . Journal of Clinical Oncology . 30 . 7 . 751–7 . March 2012 . 22291082 . 10.1200/JCO.2011.38.0345 . 3295551.