ARHGDIG explained

Rho GDP-dissociation inhibitor 3 is a protein that in humans is encoded by the ARHGDIG gene.^{[1] [2] [3]}

Interactions

ARHGDIG has been shown to interact with RHOB.^[4]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B . RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG . J. Biol. Chem. . 271 . 48 . 30366–74 . 1997 . 8939998 . 10.1074/jbc.271.48.30366 . free .
• Adra CN, Iyengar AR, Syed FA, Kanaan IN, Rilo HL, Yu W, Kheraj R, Lin SR, Horiuchi T, Khan S, Weremowicz S, Lim B, Morton CC, Higgs DR . Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3 . Genomics . 53 . 1 . 104–9 . 1998 . 9787082 . 10.1006/geno.1998.5482 .
• Elenich LA, Nandi D, Kent AE, McCluskey TS, Cruz M, Iyer MN, Woodward EC, Conn CW, Ochoa AL, Ginsburg DB, Monaco JJ . The complete primary structure of mouse 20S proteasomes . Immunogenetics . 49 . 10 . 835–42 . 1999 . 10436176 . 10.1007/s002510050562 . 20977116 .
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B . The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function . Mol. Cell. Biol. . 22 . 4 . 1158–71 . 2002 . 11809807 . 134637 . 10.1128/MCB.22.4.1158-1171.2002 .
• del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA . Integrins regulate Rac targeting by internalization of membrane domains . Science . 303 . 5659 . 839–42 . 2004 . 14764880 . 10.1126/science.1092571 . 2004Sci...303..839D . 22871247 .
• Dransart E, Morin A, Cherfils J, Olofsson B . Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors . J. Biol. Chem. . 280 . 6 . 4674–83 . 2005 . 15513926 . 10.1074/jbc.M409741200 . free .

Notes and References

1. Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B . RhoGDIγ: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas . Proc Natl Acad Sci U S A . 94 . 9 . 4279–84 . May 1997 . 9113980 . 20713 . 10.1073/pnas.94.9.4279 . 1997PNAS...94.4279A . free .
2. Brunet N, Morin A, Olofsson B . RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain . Traffic . 3 . 5 . 342–57 . Apr 2002 . 11967128 . 10.1034/j.1600-0854.2002.30504.x . 19351109 . free .
3. Web site: Entrez Gene: ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma.
4. Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B . RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG . J. Biol. Chem. . 271 . 48 . 30366–74 . Nov 1996 . 8939998 . 10.1074/jbc.271.48.30366 . free .