Aquaporin-5 Explained

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.^{[1] [2]}

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions.^[2] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.^[2]

Further reading

• Verkman AS . Role of aquaporin water channels in eye function. . Exp. Eye Res. . 76 . 2 . 137–43 . 2003 . 12565800 . 10.1016/S0014-4835(02)00303-2 .
• Ma T, Yang B, Umenishi F, Verkman AS . Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. . Genomics . 43 . 3 . 387–9 . 1997 . 9268644 . 10.1006/geno.1997.4836 .
• Smith JK, Siddiqui AA, Modica LA . Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands. . J. Interferon Cytokine Res. . 19 . 8 . 929–35 . 1999 . 10476940 . 10.1089/107999099313479 . etal.
• Kreda SM, Gynn MC, Fenstermacher DA . Expression and localization of epithelial aquaporins in the adult human lung. . Am. J. Respir. Cell Mol. Biol. . 24 . 3 . 224–34 . 2001 . 11245621 . 10.1165/ajrcmb.24.3.4367. 12825671 . etal.
• Gresz V, Kwon TH, Hurley PT . Identification and localization of aquaporin water channels in human salivary glands. . Am. J. Physiol. Gastrointest. Liver Physiol. . 281 . 1 . G247–54 . 2001 . 11408278 . 10.1152/ajpgi.2001.281.1.G247. etal.
• Nejsum LN, Kwon TH, Jensen UB . Functional requirement of aquaporin-5 in plasma membranes of sweat glands. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 1 . 511–6 . 2002 . 11773623 . 10.1073/pnas.012588099 . 117591 . 2002PNAS...99..511N . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Burghardt B, Elkaer ML, Kwon TH . Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. . Gut . 52 . 7 . 1008–16 . 2003 . 12801959 . 10.1136/gut.52.7.1008 . 1773699 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Chen Z, Wang X, Gao L . Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells. . Biochem. Biophys. Res. Commun. . 342 . 3 . 775–81 . 2006 . 16500622 . 10.1016/j.bbrc.2006.01.103 . etal.
• Sidhaye VK, Güler AD, Schweitzer KS . Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 12 . 4747–52 . 2006 . 16537379 . 10.1073/pnas.0511211103 . 1450241 . 2006PNAS..103.4747S . etal. free .
• Pedersen PS, Braunstein TH, Jørgensen A . Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress. . Pflügers Arch. . 453 . 6 . 777–85 . 2007 . 17043812 . 10.1007/s00424-006-0157-3 . 6205954 . etal.
• Skowron-zwarg M, Boland S, Caruso N . Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation. . Exp. Cell Res. . 313 . 12 . 2695–702 . 2007 . 17553491 . 10.1016/j.yexcr.2007.02.035 . etal.

Notes and References

1. Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P . The human Aquaporin-5 gene. Molecular characterization and chromosomal localization . J Biol Chem . 271 . 15 . 8599–604 . Jun 1996 . 8621489 . 10.1074/jbc.271.15.8599. free .
2. Web site: Entrez Gene: AQP5 aquaporin 5.