AP4B1 explained

AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.^{[1] [2]}

Function

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1)^[2]

Interactions

AP4B1 has been shown to interact with AP4M1.^[3]

Clinical relevance

AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.^{[4] [5]}

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human AP-4 complex subunit beta-1

Further reading

• Hirst J, Bright NA, Rous B, Robinson MS . Characterization of a fourth adaptor-related protein complex . Mol. Biol. Cell . 10 . 8 . 2787–802 . 1999 . 10436028 . 10.1091/mbc.10.8.2787. 25515 .
• Takatsu H, Futatsumori M, Yoshino K . Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system . Biochem. Biophys. Res. Commun. . 284 . 4 . 1083–9 . 2001 . 11409905 . 10.1006/bbrc.2001.5081 . etal.
• Cayrol C, Cougoule C, Wright M . The beta2-adaptin clathrin adaptor interacts with the mitotic checkpoint kinase BubR1 . Biochem. Biophys. Res. Commun. . 298 . 5 . 720–30 . 2003 . 12419313 . 10.1016/S0006-291X(02)02522-6 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.

Notes and References

1. Dell'Angelica EC, Mullins C, Bonifacino JS . AP-4, a novel protein complex related to clathrin adaptors . J Biol Chem . 274 . 11 . 7278–85 . Apr 1999 . 10066790 . 10.1074/jbc.274.11.7278 . free .
2. Web site: Entrez Gene: AP4B1 adaptor-related protein complex 4, beta 1 subunit.
3. Hirst J, Bright NA, Rous B, Robinson MS . Characterization of a fourth adaptor-related protein complex . Mol. Biol. Cell . 10 . 8 . 2787–802 . August 1999 . 10436028 . 25515 . 10.1091/mbc.10.8.2787.
4. Abou Jamra R, Philippe O, Raas-Rothschild A, Eck SH, Graf E, Buchert R, Borck G, Ekici A, Brockschmidt FF, Nöthen MM, Munnich A, Strom TM, Reis A, Colleaux L . Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature . Am. J. Hum. Genet. . 88 . 6 . 788–95 . June 2011 . 21620353 . 3113253 . 10.1016/j.ajhg.2011.04.019 .
5. Web site: Cerebral Palsy Linked to Genetic Abnormalities. medscape.