AP3D1 explained

AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.^{[1] [2] [3]}

Function

AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM]

Interactions

AP3D1 has been shown to interact with SYBL1.^[4]

Further reading

• Höning S, Sandoval IV, von Figura K . A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3 . The EMBO Journal . 17 . 5 . 1304–14 . Aug 1998 . 9482728 . 1170479 . 10.1093/emboj/17.5.1304 .
• Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M . Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles . Neuron . 21 . 1 . 111–22 . Jul 1998 . 9697856 . 10.1016/S0896-6273(00)80519-X . 17237941 . free .
• Rehling P, Darsow T, Katzmann DJ, Emr SD . Formation of AP-3 transport intermediates requires Vps41 function . Nature Cell Biology . 1 . 6 . 346–53 . 2000 . 10559961 . 10.1038/14037 . 24932376 .
• Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC . Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif . Virology . 271 . 1 . 9–17 . May 2000 . 10814565 . 10.1006/viro.2000.0277 . free .
• Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G . PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic . The EMBO Journal . 20 . 9 . 2191–201 . May 2001 . 11331585 . 125242 . 10.1093/emboj/20.9.2191 .
• Austin C, Boehm M, Tooze SA . Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3 . Biochemistry . 41 . 14 . 4669–77 . Apr 2002 . 11926829 . 10.1021/bi016064j .
• Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J . HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes . The Journal of Biological Chemistry . 278 . 10 . 8725–32 . Mar 2003 . 12486136 . 10.1074/jbc.M210115200 . free .
• Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA . Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1 . Developmental Cell . 5 . 3 . 513–21 . Sep 2003 . 12967569 . 10.1016/S1534-5807(03)00234-X . free .
• Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V . The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation . Molecular Biology of the Cell . 15 . 2 . 575–87 . Feb 2004 . 14657250 . 329249 . 10.1091/mbc.E03-06-0401 .
• Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS . An ear-core interaction regulates the recruitment of the AP-3 complex to membranes . Developmental Cell . 7 . 4 . 619–25 . Oct 2004 . 15469849 . 10.1016/j.devcel.2004.08.009 . free .
• Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC . Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes . Journal of Virology . 79 . 4 . 2066–78 . Feb 2005 . 15681409 . 546596 . 10.1128/JVI.79.4.2066-2078.2005 .
• Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P . AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly . Cell . 120 . 5 . 663–74 . Mar 2005 . 15766529 . 10.1016/j.cell.2004.12.023 . 14528434 . free .
• Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G . Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes . Molecular Biology of the Cell . 16 . 11 . 5356–72 . 2006 . 16162817 . 1266432 . 10.1091/mbc.E05-07-0626 .

Notes and References

1. Simpson F, Peden AA, Christopoulou L, Robinson MS . Characterization of the adaptor-related protein complex, AP-3 . The Journal of Cell Biology . 137 . 4 . 835–45 . May 1997 . 9151686 . 2139840 . 10.1083/jcb.137.4.835 .
2. Ooi CE, Moreira JE, Dell'Angelica EC, Poy G, Wassarman DA, Bonifacino JS . Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet . The EMBO Journal . 16 . 15 . 4508–18 . Aug 1997 . 9303295 . 1170077 . 10.1093/emboj/16.15.4508 .
3. Web site: Entrez Gene: AP3D1 adaptor-related protein complex 3, delta 1 subunit.
4. Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T . A dual mechanism controlling the localization and function of exocytic v-SNAREs . Proceedings of the National Academy of Sciences of the United States of America . 100 . 15 . 9011–6 . Jul 2003 . 12853575 . 166429 . 10.1073/pnas.1431910100 . 2003PNAS..100.9011M . free .