ANXA8L2 explained

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.^[1]

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.

Further reading

• Gerke V, Moss SE . Annexins: from structure to function. . Physiol. Rev. . 82 . 2 . 331–71 . 2002 . 11917092 . 10.1152/physrev.00030.2001 .
• Gerke V, Creutz CE, Moss SE . Annexins: linking Ca2+ signaling to membrane dynamics. . Nat. Rev. Mol. Cell Biol. . 6 . 6 . 449–61 . 2005 . 15928709 . 10.1038/nrm1661 . 37526262 .
• Chang KS, Wang G, Freireich EJ . Specific expression of the annexin VIII gene in acute promyelocytic leukemia. . Blood . 79 . 7 . 1802–10 . 1992 . 1313714 . 10.1182/blood.V79.7.1802.1802. etal. free .
• Chambers JA, Gardner E, Hauptmann R . TaqI polymorphisms at the annexin VIII locus (ANX8). . Hum. Mol. Genet. . 1 . 7 . 550 . 1993 . 1364010 . 10.1093/hmg/1.7.550 . etal. free .
• Hauptmann R, Maurer-Fogy I, Krystek E . Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. . Eur. J. Biochem. . 185 . 1 . 63–71 . 1989 . 2530088 . 10.1111/j.1432-1033.1989.tb15082.x . etal. free .
• Sarkar A, Yang P, Fan YH . Regulation of the expression of annexin VIII in acute promyelocytic leukemia. . Blood . 84 . 1 . 279–86 . 1994 . 8018923 . 10.1182/blood.V84.1.279.279. etal. free .
• Reutelingsperger CP, van Heerde W, Hauptmann R . Differential tissue expression of Annexin VIII in human. . FEBS Lett. . 349 . 1 . 120–4 . 1994 . 8045287 . 10.1016/0014-5793(94)00559-1 . 8928858 . etal. free . 1994FEBSL.349..120R .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10. . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Stein T, Price KN, Morris JS . Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. . Clin. Cancer Res. . 11 . 19 Pt 1 . 6872–9 . 2006 . 16203777 . 10.1158/1078-0432.CCR-05-0547 . etal. free .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Goebeler V, Ruhe D, Gerke V, Rescher U . Annexin A8 displays unique phospholipid and F-actin binding properties. . FEBS Lett. . 580 . 10 . 2430–4 . 2006 . 16638567 . 10.1016/j.febslet.2006.03.076 . 22336528 . free . 2006FEBSL.580.2430G .

Notes and References

1. Web site: Entrez Gene: ANXA8 annexin A8.