AC-90179 explained

AC-90179 is a piperidine derivative which acts as an inverse agonist at the 5-HT_2A serotonin receptor and an antagonist at 5-HT_2C. It was developed as a potential antipsychotic but was not pursued for medical applications due to poor oral bioavailability; however, it continues to be used as a tool compound in pharmacological research.^{[1] [2]}

See also

• Pimavanserin
• Volinanserin

Notes and References

1. Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, Harvey SC, Donohue E, Hansen HC, Andersson CM, Spalding TA, Gibson DF, Krebs-Thomson K, Powell SB, Geyer MA, Hacksell U, Brann MR . 5-hydroxytryptamine2A receptor inverse agonists as antipsychotics . The Journal of Pharmacology and Experimental Therapeutics . 299 . 1 . 268–76 . October 2001 . 11561089 .
2. Vanover KE, Harvey SC, Son T, Bradley SR, Kold H, Makhay M, Veinbergs I, Spalding TA, Weiner DM, Andersson CM, Tolf BR, Brann MR, Hacksell U, Davis RE . 12205122 . Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist . The Journal of Pharmacology and Experimental Therapeutics . 310 . 3 . 943–51 . September 2004 . 15102927 . 10.1124/jpet.104.066688 .