A-41988 Explained

A-41988 (BW29Y) is an analgesic drug which acts as a cannabinoid agonist. It was developed by Abbott Laboratories in the 1970s,[1] [2] and researched for potential use in the treatment of glaucoma,[3] but never commercialised.

See also

Notes and References

  1. Winn M, Arendsen D, Dodge P, Dren A, Dunnigan D, Hallas R, Hwang K, Kyncl J, Lee YH, Plotnikoff N, Young P, Zaugg H . 6 . Drugs derived from cannabinoids. 5. delta6a,10a-Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains . Journal of Medicinal Chemistry . 19 . 4 . 461–71 . April 1976 . 817021 . 10.1021/jm00226a003 .
  2. Guterman A, Somani P, Bachand RT . Phase-I evaluation of 5-5-dimethyl-10-hydroxy-8-[5-(4-fluorophenyl)-2-pentyl]-2-(2-propynyl-1, 2, 3, 4-tetrahydro-5h-[1] benzopyrano [3, 4-d] pyridine (a-41988)-novel benzopyran derivative . Clinical Pharmacology and Therapeutics . 1979 . 25 . 227 .
  3. Tiedeman JS, Shields MB, Weber PA, Crow JW, Cocchetto DM, Harris WA, Howes JF . Effect of synthetic cannabinoids on elevated intraocular pressure . Ophthalmology . 88 . 3 . 270–7 . March 1981 . 7015221 . 10.1016/s0161-6420(81)35052-0 .

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