5α-Dihydronormethandrone explained

5α-Dihydronormethandrone (5α-DHNMT; developmental code name RU-575), also known as 17α-methyl-4,5α-dihydro-19-nortestosterone or as 17α-methyl-5α-estran-17β-ol-3-one, is an androgen/anabolic steroid and a likely metabolite of normethandrone formed by 5α-reductase.^[1] Analogously to nandrolone and its 5α-reduced metabolite 5α-dihydronandrolone, 5α-DHNMT shows reduced affinity for the androgen receptor relative to normethandrone.^[2] Its affinity for the androgen receptor is specifically about 33 to 60% of that of normethandrone.

See also

• 5α-Dihydronorethandrolone
• 5α-Dihydronandrolone
• 5α-Dihydronorethisterone
• 5α-Dihydrolevonorgestrel

Notes and References

1. Schjølberg, T. H. (2013). In Vitro Synthesis of Metabolites of three Anabolic Androgenic Steroids, by Human Liver Microsomes (Master's thesis, Institutt for bioteknologi). https://brage.bibsys.no/xmlui/handle/11250/246018
2. Ojasoo T, Delettré J, Mornon JP, Turpin-VanDycke C, Raynaud JP . Towards the mapping of the progesterone and androgen receptors . J. Steroid Biochem. . 27 . 1–3 . 255–69 . 1987 . 3695484 . 10.1016/0022-4731(87)90317-7 .