4-hydroxybenzoate polyprenyltransferase explained
| 4-hydroxybenzoate polyprenyltransferase |
| Ec Number: | 2.5.1.39 |
| Cas Number: | 9030-77-7 |
| Go Code: | 0047293 |
In enzymology, a 4-hydroxybenzoate polyprenyltransferase is an enzyme that catalyzes the chemical reaction
a polyprenyl diphosphate + 4-hydroxybenzoate
diphosphate + a 4-hydroxy-3-polyprenylbenzoate
Thus, the two substrates of this enzyme are a polyprenyl diphosphate and 4-hydroxybenzoate, whereas its two products are diphosphate and 4-hydroxy-3-polyprenylbenzoate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. This enzyme participates in ubiquinone biosynthesis.[1]
Nomenclature
The systematic name of this enzyme class is polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase. Other names in common use include:
- nonaprenyl-4-hydroxybenzoate transferase,
- 4-hydroxybenzoate transferase,
- p-hydroxybenzoate dimethylallyltransferase,
- p-hydroxybenzoate polyprenyltransferase,
- p-hydroxybenzoic acid-polyprenyl transferase,
- p-hydroxybenzoic-polyprenyl transferase, and
- 4-hydroxybenzoate nonaprenyltransferase
References
- Kalen A, Appelkvist EL, Chojnacki T, Dallner G . 1990 . Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver . J. Biol. Chem. . 265 . 1158–64 . 2295606 . 2 .
Notes and References
- Biochim Biophys Acta . 1994-04-14 . 1212 . 1 . 93–102 . Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli . Melzer M, Heide L . 8155731 . 10.1016/0005-2760(94)90193-7.
