4-Methylcathinone Explained
4-Methylcathinone (also known as Nor-Mephedrone, 4-MC and NSC-60487), is a stimulant drug of the cathinone chemical class. It is a metabolite of the better known drug mephedrone (4-methylmethcathinone).[1] [2] [3] [4]
4-Methylcathinone displays a 2.4-fold selectivity to promote monoamine release via DAT over SERT as opposed to 309-fold selectivity for cathinone.[5] It also releases norepinephrine.
See also
Notes and References
- Web site: nor-Mephedrone . Cayman Chemical . 27 June 2015.
- Meyer MR, Wilhelm J, Peters FT, Maurer HH . Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry . Analytical and Bioanalytical Chemistry . 397 . 3 . 1225–33 . June 2010 . 20333362 . 10.1007/s00216-010-3636-5 . 21471611 .
- Pedersen AJ, Reitzel LA, Johansen SS, Linnet K . In vitro metabolism studies on mephedrone and analysis of forensic cases . Drug Testing and Analysis . 5 . 6 . 430–8 . June 2013 . 22573603 . 10.1002/dta.1369 .
- Dargan PI, Sedefov R, Gallegos A, Wood DM . The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone) . Drug Testing and Analysis . 3 . 7–8 . 454–63 . July–August 2011 . 21755604 . 10.1002/dta.312 .
- Hutsell BA, Baumann MH, Partilla JS, Banks ML, Vekariya R, Glennon RA, Negus SS . Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats . European Neuropsychopharmacology . 26 . 2 . 288–297 . February 2016 . 26738428 . 5331761 . 10.1016/j.euroneuro.2015.12.010 .
