3-Nitrobenzaldehyde Explained

3-Nitrobenzaldehyde is an organic compound with the formula . It is one of three isomers of nitrobenzaldehyde. It contains a nitro group meta-substituted to the aldehyde.

3-Nitrobenzaldehyde is the primary product obtained via the mono-nitration of benzaldehyde with nitric acid.[1]

Product distribution is about 19% for the ortho-, 72% for the meta- and 9% for the para isomers.

Uses

3-Nitrobenzaldehyde is a precursor to the drug Tipranavir. It is a mainstay in the synthesis of Dihydropyridine calcium channel blockers. Via selective reduction of the nitro group, it is a precursor to the diazonium salt.[2]

References

  1. Book: 10.1002/14356007.a03_463.pub2 . Benzaldehyde . Ullmann's Encyclopedia of Industrial Chemistry . 2011 . Brühne . Friedrich . Wright . Elaine . 978-3-527-30385-4 .
  2. Johannes S. Buck and Walter S. Ide. 10.15227/orgsyn.013.0028. m-Chlorobenzaldehyde . Organic Syntheses . 1933 . 13 . 28 .