The 2024–25 AFC Champions League Elite knockout stage will begin on 3 March with the round of 16 and end on 4 May 2025, with the final to decide the champions of the 2024–25 AFC Champions League Elite.[1] A total of 16 teams compete in the knockout stage.
The top eight teams in the league stage from each region advance to the round of 16, with both West Region and East Region having eight qualified teams.
| width=90 | Region | Team | Qualified (Position TBD) | |
|---|---|---|---|---|
| West Region | 1 | Al-Ahli Al-Hilal Al-Nassr Al-Sadd Al-Wasl | ||
| 2 | ||||
| 3 | ||||
| 4 | ||||
| 5 | ||||
| 6 | ||||
| 7 | ||||
| 8 | ||||
| East Region | 1 | |||
| 2 | ||||
| 3 | ||||
| 4 | ||||
| 5 | ||||
| 6 | ||||
| 7 | ||||
| 8 |
In the knockout stage, the 16 teams will play a single-elimination tournament. The round of 16 will see each team play against team from its region, with cross-regional pairings made from the quarter-finals. Each tie will be played as a single match, except the round of 16 which will be played on a home-and-away two-legged basis. Extra time and a penalty shoot-out will be used to decide the winner if necessary (Regulations Article 10).[2] The match-ups for the quarter-finals, semi-finals, and final will be determined at a single draw event.
The schedule of the knockout component is as follows.[1]
| Stage | Round | Draw date | West region | East region |
|---|---|---|---|---|
| Round of 16 | No draw | 3–4 and 10–11 March 2025 | 4–5 and 11–12 March 2025 | |
| Final stage | Quarter-finals | TBD | 25–26 April 2025 | |
| Semi-finals | 29–30 April 2025 | |||
| Final | 4 May 2025 | |||
The first legs will be played on 3–5 March, and the second legs will be played on 10–12 March 2025.