| Champ: |  Elisabetta Cocciaretto |
| Runner: | Sara Errani |
| Score: | 5–7, 6–4, 7–5 |
| Before Year: | no |
See main article: 2023 San Luis Open Challenger.
This was the first edition of the tournament as a part of the 2023 WTA 125 tournaments.[1]
Elisabetta Cocciaretto won the title, defeating Sara Errani in the final, 5–7, 6–4, 7–5.[2]