| Date: | July 25–31 |
| Edition: | 5th |
| Category: | ATP Challenger Tour |
| Surface: | Hard – outdoors |
| Location: | Winnipeg, Manitoba, Canada |
| Venue: | Winnipeg Lawn Tennis Club |
| Champs: |  Emilio Gómez |
| Champd: |  Billy Harris /  Kelsey Stevenson |
| Main Name: | Winnipeg Challenger |
| Before Year: | 2019 |
The 2022 Winnipeg National Bank Challenger was a professional tennis tournament played on outdoor hard courts. It was the 5th edition of the tournament and part of the 2022 ATP Challenger Tour. It took place in Winnipeg, Manitoba, Canada between July 25 and July 31, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United Kingdom | Liam Broady | 133 | 1 | |
| Ecuador | Emilio Gómez | 138 | 2 | |
| Canada | Vasek Pospisil | 139 | 3 | |
 United States | Michael Mmoh | 162 | 4 | |
 Japan | Kaichi Uchida | 172 | 5 | |
| Wu Tung-lin | 179 | 6 | ||
| Gijs Brouwer | 201 | 7 | ||
 Argentina | Genaro Alberto Olivieri | 209 | 8 |
The following players received wildcards into the singles main draw:
Gabriel Diallo Liam Draxl Jaden WeekesThe following players received entry from the qualifying draw:
Juan Carlos Aguilar Alafia Ayeni Kyle Edmund Govind Nanda Zachary Svajda Evan ZhuThe following player received entry as a lucky loser:
See main article: article and 2022 Winnipeg National Bank Challenger – Singles.
Emilio Gómez def. Alexis Galarneau 6–3, 7–6(7–4). Billy Harris / Kelsey Stevenson def. Max Schnur / 
John-Patrick Smith 2–6, 7–6(11–9), [10–8].