| Date: | 14–20 November 2022 |
| Edition: | 2nd |
| Surface: | Clay |
| Location: | Buenos Aires, Argentina |
| Venue: | Buenos Aires Lawn Tennis Club |
| Category: | WTA 125 |
| Prize Money: | $115,000 |
| Champs: |  Panna Udvardy |
| Champd: |  Irina Bara /  Sara Errani |
| Main Name: | WTA Argentine Open |
The 2022 WTA Argentina Open was a professional tennis tournament played on outdoor clay courts. It was the second edition of the tournament which is also part of the 2022 WTA 125 tournaments. It took place at the Buenos Aires Lawn Tennis Club in Buenos Aires, Argentina between 14 and 20 November 2022.[1] [2]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Egypt | ||||
 Montenegro | Danka Kovinić | 79 | 2 | |
| Hungary | Panna Udvardy | 83 | 3 | |
 Austria | Julia Grabher | 84 | 4 | |
| Tamara Zidanšek | 87 | 5 | ||
| Italy | Sara Errani | 109 | 6 | |
| Hungary | Réka Luca Jani | 111 | 7 | |
 Brazil | Laura Pigossi | 114 | 8 | |
 Korea, Republic of | Jang Su-jeong | 115 | 9 |
The following players received wildcards into the singles main draw:
Chiara Di Genova Paula Ormaechea Nadia Podoroska Solana SierraThe following players received entry from the qualifying draw:
The following players received entry into the main draw as lucky losers:
Carolina Alves → replaced by 
Sára Bejlek Gabriela Lee → replaced by 
Ekaterine Gorgodze
Elizabeth Mandlik → replaced by Irina Bara
Yuki Naito → replaced by 
İpek Öz
Camila Osorio → replaced by María Lourdes Carlé
Chloé Paquet → replaced by Brenda Fruhvirtová
Nuria Párrizas Díaz → replaced by 
Marcela Zacarías Mayar Sherif → replaced by Darya Astakhova| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Hungary | Tímea Babos | Georgia | Ekaterine Gorgodze | 172 | 1 | |
| Brazil | Ingrid Gamarra Martins | Brazil | Luisa Stefani | 187 | 2 | |
 Venezuela, Bolivarian Republic of | Andrea Gámiz | Eva Vedder | 217 | 3 | ||
| United States | Jessie Aney | United States | Ingrid Neel | 229 | 4 |
The following pair received a wildcard into the doubles main draw:
See main article: 2022 WTA Argentina Open – Singles.
Panna Udvardy def. Danka Kovinić 6–4, 6–1See main article: 2022 WTA Argentina Open – Doubles.
Irina Bara / Sara Errani def. Jang Su-jeong / 
You Xiaodi 6–1, 7–5