The 2022 OFC Champions League knockout stage will be played from 14 to 17 August 2022. A total of four teams will compete in the knockout stage to decide the champions of the 2022 OFC Champions League.
The winners and runners-up of each of the two groups in the group stage advanced to the semi-finals.
| Group | Winners | Runners-up | |
|---|---|---|---|
| A | Vénus | Central Coast | |
| B |  Auckland City | Hienghène Sport |
The schedule of each round was as follows.
| Round | Match dates | |
|---|---|---|
| Semi-finals | 14 August 2022 | |
| Final | 17 August 2022 at Ngahue Reserve, Auckland |
The bracket was determined as follows:
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See main article: 2022 OFC Champions League Final. In the final, the two semi-final winners played each other. The final will be played on 17 August 2022.