| Date: | 25 April – 1 May |
| Edition: | 14th |
| Surface: | Clay |
| Location: | Rome, Italy |
| Champs: |  Franco Agamenone |
| Champd: | Jesper de Jong / Bart Stevens |
| Before Name: | Garden Open II |
The 2022 Garden Open was a professional tennis tournament played on clay courts. It was the fourteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Rome, Italy between 25 April and 1 May 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Quentin Halys | 102 | 1 | |
 United Kingdom | Jack Draper | 124 | 2 | |
| Italy | Flavio Cobolli | 143 | 3 | |
 Australia | ||||
 Serbia | Nikola Milojević | 149 | 5 | |
| France | Manuel Guinard | 152 | 6 | |
| France | Hugo Grenier | 156 | 7 | |
| France | Gilles Simon | 159 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2022 Garden Open – Singles.
Franco Agamenone def. Gian Marco Moroni 6–1, 6–4.See main article: 2022 Garden Open – Doubles.
Sadio Doumbia / Fabien Reboul 3–6, 7–5, [10–8].
