| Year: | 2022 |
| Team: | East Tennessee State Buccaneers |
| Sport: | football |
| Conference: | Southern Conference |
| Short Conf: | SoCon |
| Record: | 3–8 |
| Conf Record: | 1–7 |
| Head Coach: | George Quarles |
| Hc Year: | 1st |
| Off Coach: | Adam Neugebauer |
| Oc Year: | 1st |
| Def Coach: | Billy Taylor |
| Dc Year: | 8th |
| Stadium: | William B. Greene Jr. Stadium |
The 2022 East Tennessee State Buccaneers football team represented East Tennessee State University as a member of the Southern Conference (SoCon) during the 2022 NCAA Division I FCS football season. The Buccaneers were led by first-year head coach George Quarles and play their home games at William B. Greene Jr. Stadium in Johnson City, Tennessee.
See also: 2022 The Citadel Bulldogs football team.
See also: 2022 Furman Paladins football team.
See also: 2022 Robert Morris Colonials football team.
See also: 2022 Chattanooga Mocs football team.
See also: 2022 VMI Keydets football team.
See also: 2022 Mercer Bears football team.
See also: 2022 Samford Bulldogs football team.
See also: 2022 Wofford Terriers football team.
See also: 2022 Western Carolina Catamounts football team.
See also: 2022 Mississippi State Bulldogs football team.