See main article: 2022 Chile Open.
Pedro Martínez defeated Sebastián Báez in the final, 4–6, 6–4, 6–4 to win the singles title at the 2022 Chile Open. It was his first ATP Tour title.
Cristian Garín was the defending champion,[1] but lost in the second round to Alejandro Tabilo.
The top four seeds received a bye into the second round.