| Season: | 2022 |
| Competition: | Cambodian League 2 |
| Dates: | 6 March – 30 October 2022 |
| Winners: | Electricite du Cambodge |
| Promoted: | ISI Dangkor Senchey Prey Veng |
| League Topscorer: | Louis Willy Ndongo (30 goals) |
| Biggest Home Win: | Soltilo Angkor 11–0 Next Step (2nd October) |
| Biggest Away Win: | Banteay Meanchey 1–13 Prey Veng (28th August) |
| Highest Scoring: | Banteay Meanchey 1–13 Prey Veng (28th August) |
| Matches: | 132 |
| Total Goals: | 556 |
| Longest Wins: | 8 matches Electricite du Cambodge |
| Longest Unbeaten: | 11 matches Electricite du Cambodge |
| Longest Losses: | 12 matches Banteay Meanchey |
| Highest Attendance: | 3,296 ISI Dangkor Senchey 4–1 National Football Academy (2nd October) |
| Prevseason: | 2021 |
| Nextseason: | 2023–24 |
The 2022 Cambodian League 2 is the 5th season of the Cambodian League 2, second-tier football league for association football clubs in Cambodia. A total of 12 football clubs are competing in the league. Electricite du Cambodge are the champion of the 2022 season; however, they are not met the requirement of national club licensing criteria alongside the third place National Police and the fourth place Koh Kong. Thus, they're ineligible for promotion. That leaves the runner up ISI Dangkor Senchey and the fifth place Prey Veng to be promoted for Cambodian Premier League next season.
| Team | Manager | Captain | Kit manufacturer | Shirt sponsor |
|---|---|---|---|---|
| Asia Euro United | Sok Veasna | Lay Raksmey | NT Sport | Asia Euro University |
| Banteay Meanchey | Yeak Chhim | Chet Sophannit | ||
| Bati Academy |  Koji Gyotoku | Football Federation of Cambodia | ||
| Electricite du Cambodge | Chhoeung Visinu | Forward Sportswear | Electricite du Cambodge | |
| ISI Dangkor Senchey |  John Botioba | Sun Sovannarith | NT Sport | ISI Palm |
| Koh Kong | Hok Sochivorn | Touch Pancharong | NT Sport | |
| National Police | Ung Kanyanith | Say Piseth | FAN | General Commissariat of National Police |
| Next Step | Yok Ary | NT Sport | ||
| Prey Veng | Tith Dina | Forward Sportswear | ||
| Siem Reap | Ly Theara | NT Sport | ||
| Soltilo Angkor | Chea Mengly | Im Vakhim | Forward Sportswear | |
| Tboung Khmum | Phon Raksmeypich | NT Sport | ||
The number of foreign players is restricted to 4 per team. A team can use 3 foreign players on the field in each game, including at least 1 player from the AFC region.
Players name in bold indicates the player is registered during the mid-season transfer window.
| Club | Player 1 | Player 2 | Player 3 | AFC Player | Former Players | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Asia Euro United | Samuel Ajayi |  Louis Willy Ndongo | Mintah Bernard Owusu | Kanta Asami | ||||||
| Banteay Meanchey |  Simone Valli |  Joslyn Ghifem Katuala | Thapa Magar Saroj | |||||||
| Bati Academy | bgcolor=#aaa | bgcolor=#aaa | bgcolor=#aaa | bgcolor=#aaa | bgcolor=#aaa | |||||
| Electricite du Cambodge | bgcolor=#aaa | bgcolor=#aaa | bgcolor=#aaa | bgcolor=#aaa | bgcolor=#aaa | |||||
| ISI Dangkor Senchey |  Abdel Kader Coulibaly | Ibrahim Abou Dicko |  Elsayed Mahmoud | Kento Fujihara | Baldwin Ngwa Victor Cabral | |||||
| Koh Kong | Abbee Ndjoo |  Umaru Samura | Thiha Zaw | Santigie Koroma | ||||||
| National Police | Andre Roland Longnyo | Rasheed Omokafe | Esoh Paul Omogba | |||||||
| Next Step | Bruno Krenkel |  Ayoub Achqaf |  Florian Charreau | Takuya Yamase | Douglas Caldas | |||||
| Prey Veng | Nduka Uche Raoul | Ekene Azike |  Chris Jastrzembski | Seon Power Alisher Mirzaev | ||||||
| Siem Reap | Cyrille Dissake | Victor Cabral | Shota Fujishiro | Ayoub Achqaf Magson Dourado | ||||||
| Soltilo Angkor | Yannick Francois | Dzarma Bata |  Atuheire Kipson | Unno Tomoyuki | ||||||
| Tbong Khmum | Santigie Koroma | Nathan Kabangu |  Mateo Zapata | |||||||
As of 30 October 2022.
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 | Louis Willy Ndongo | Asia Euro United | 30 | |
| 2 | Abbee Ndjoo | Koh Kong | 25 | |
| 3 | Abdel Kader Coulibaly | ISI Dangkor Senchey | 20 | |
| 4 | Thiha Zaw | Koh Kong | 15 | |
| 5 | Chhout Senteang | Electricite du Cambodge | 14 | |
| Sary Taimou | Koh Kong | |||
| Ekene Azike | Prey Veng | |||
| 8 | Yannick Francois | Soltilo Angkor | 11 | |
| Esoh Paul Omogba | National Police | |||
| 10 | Bruno Krenkel | Next Step | 10 |