| Before Year: | 2021 |
| Champ: |  Albert Ramos Viñolas |
| Runner: | Alejandro Tabilo |
| Score: | 4–6, 6–3, 6–4 |
| Draw: | 28 (4Q, 3WC) |
| Seeds: | 8 |
| Type: | Singles Doubles |
| After Year: | 2023 |
See main article: 2022 Córdoba Open.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Juan Manuel Cerúndolo was the defending champion,[1] but withdrew with a right leg injury before the tournament began.
The top four seeds received a bye into the second round.