| Year: | 2021 |
| Team: | Southeast Missouri State Redhawks |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 4–7 |
| Conf Record: | 4–2 |
| Head Coach: | Tom Matukewicz |
| Hc Year: | 8th |
| Off Coach: | Jeromy McDowell |
| Oc Year: | 4th |
| Def Coach: | Bryce Saia |
| Dc Year: | 8th |
| Stadium: | Houck Stadium |
The 2021 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2021 NCAA Division I FCS football season. Led by eighth-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 4–7 with a mark of 4–2 in conference play, tying for second place in the OVC. Southeast Missouri State played home games at Houck Stadium in Cape Girardeau, Missouri.