| Date: | 19–25 July 2021 |
| Edition: | 16th |
| Surface: | Hard |
| Location: | Nur-Sultan, Kazakhstan |
| Champs: |  Andrey Kuznetsov |
| Champd: | Hsu Yu-hsiou / Benjamin Lock |
| Before Year: | 2021 |
| Before Name: | President's Cup (tennis) |
| Main Name: | President's Cup (tennis) President's Cup |
| After Name: | President's Cup (tennis) |
The 2021 President's Cup II was a professional tennis tournament played on outdoor hard courts. It was the sixteenth edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Nur-Sultan, Kazakhstan between 19 and 25 July 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Russian Federation | ||||
 Ukraine | Sergiy Stakhovsky | 226 | 2 | |
 United Kingdom | Jay Clarke | 243 | 3 | |
 France | Hugo Grenier | 253 | 4 | |
 Canada | Peter Polansky | 254 | 5 | |
| Jesper de Jong | 263 | 6 | ||
| Tseng Chun-hsin | 265 | 7 | ||
| Wu Tung-lin | 268 | 8 |
The following players received wildcards into the singles main draw:
Grigoriy Lomakin Dostanbek Tashbulatov Beibit ZhukayevThe following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 President's Cup II – Singles.
Andrey Kuznetsov def. 
Jason Kubler 6–3, 2–1 ret.See main article: 2021 President's Cup II – Doubles.
Oleksii Krutykh / Grigoriy Lomakin 6–3, 6–4.
