| Year: | 2021 |
| Team: | Pittsburgh Panthers |
| Sport: | football |
| Conference: | Atlantic Coast Conference |
| Division: | Coastal Division |
| Short Conf: | ACC |
| Coachrank: | 13 |
| Aprank: | 13 |
| Record: | 11–3 |
| Conf Record: | 7–1 |
| Head Coach: | Pat Narduzzi |
| Hc Year: | 7th |
| Off Coach: | Mark Whipple |
| Oc Year: | 3rd |
| Off Scheme: | Pro-style |
| Def Coach: | Randy Bates |
| Dc Year: | 4th |
| Def Scheme: | 4–3 |
| Stadium: | Heinz Field |
| Champion: | Lambert-Meadowlands Trophy ACC champion ACC Coastal Division champion |
| Conf Champ: | ACC Championship Game |
| Conf Champ Result: | W 45–21 vs. Wake Forest |
| Bowl: | Peach Bowl |
| Bowl Result: | L 21–31 vs. Michigan State |
The 2021 Pittsburgh Panthers football team represented the University of Pittsburgh in the 2021 NCAA Division I FBS football season. The Panthers were led by seventh-year head coach Pat Narduzzi and played their home games at Heinz Field. They competed in the Atlantic Coast Conference (ACC), marking Pitt's ninth season as a member of the ACC. The Panthers won the ACC Championship with a record of 11–2 and a 45–21 victory over Wake Forest in the 2021 ACC Championship Game, becoming the first school other than Clemson or Florida State to win the conference championship since Virginia Tech in 2010.
Source:[1]
See also: 2021 UMass Minutemen football team.
See also: 2021 Tennessee Volunteers football team.
See also: 2021 Western Michigan Broncos football team.
See also: 2021 New Hampshire Wildcats football team.
See also: 2021 Georgia Tech Yellow Jackets football team.
See also: 2021 Virginia Tech Hokies football team.
See also: 2021 Clemson Tigers football team.
See also: 2021 Miami Hurricanes football team.
See also: 2021 Duke Blue Devils football team.
See also: 2021 North Carolina Tar Heels football team.
See also: 2021 Virginia Cavaliers football team.
See also: 2021 Syracuse Orange football team and Pittsburgh-Syracuse football rivalry.
See also: 2021 Wake Forest Demon Deacons football team and 2021 ACC Championship Game.
See also: 2021 Michigan State Spartans football team and 2021 Peach Bowl (December).
See also: 2022 NFL draft.
| 1 | 20 | Kenny Pickett | QB | Pittsburgh Steelers | |
| 4 | 115 | Damarri Mathis | CB | Denver Broncos |