The 2021 Open de Tenis Ciudad de Pozoblanco was a professional tennis tournament played on hard courts. It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Pozoblanco, Spain between 19 and 25 July 2021.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Benjamin Bonzi | 108 | 1 | |
| France | Grégoire Barrère | 137 | 2 | |
 Turkey | Altuğ Çelikbilek | 199 | 3 | |
| Turkey | Cem İlkel | 204 | 4 | |
| France | Maxime Janvier | 229 | 5 | |
| Borna Gojo | 235 | 6 | ||
| Yannick Maden | 241 | 7 | ||
 Spain | Nicola Kuhn | 250 | 8 |
The following players received wildcards into the singles main draw:
Nicolás Álvarez Varona Alberto Barroso Campos Blas Ruiz RomeroThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2021 Open de Tenis Ciudad de Pozoblanco – Singles.
Altuğ Çelikbilek def. Cem İlkel 6–1, 6–7(2–7), 6–3.See main article: 2021 Open de Tenis Ciudad de Pozoblanco – Doubles.
Diego Hidalgo / Sergio Martos Gornés 5–7, 7–6(7–4), [10–5].
