| Year: | 2021 |
| Team: | North Carolina Central Eagles |
| Sport: | football |
| Conference: | Mid-Eastern Athletic Conference |
| Short Conf: | MEAC |
| Record: | 6–5 |
| Conf Record: | 4–1 |
| Head Coach: | Trei Oliver |
| Hc Year: | 2nd |
| Off Coach: | Matt Leone |
| Oc Year: | 1st |
| Def Coach: | Juan Navarro |
| Dc Year: | 1st |
| Stadium: | O'Kelly–Riddick Stadium |
| Prev Year: | 2019 |
The 2021 North Carolina Central Eagles football team represented North Carolina Central University as a member of the Mid-Eastern Athletic Conference (MEAC) during the 2021 NCAA Division I FCS football season. Led by second-year head coach Trei Oliver, the Eagles compiled an overall record of 6–5 with a mark of 4–1, placing second in the MEAC. North Carolina Central played home games at O'Kelly–Riddick Stadium in Durham, North Carolina.
See also: 2021 Alcorn State Braves football team, MEAC/SWAC Challenge and College GameDay (football TV program).
| style= | Pregame line! | style= | Over/under |
|---|---|---|---|
| ALCN –15.5 | 53 |
| Statistics | Alcorn State | North Carolina Central |
|---|---|---|
| First downs | 18 | 19 |
| Total yards | 325 | 391 |
| Rushing yards | 171 | 207 |
| Passing yards | 154 | 184 |
| Turnovers | 1 | 2 |
| Time of possession | 28:20 | 31:25 |
| Team | Category | Player | Statistics |
|---|---|---|---|
| Alcorn State | Passing | Felix Harper | 17/27, 154 yards, 2 TDs |
| Rushing | Stadford Anderson | 11 carries, 128 yards | |
| Receiving | Juan Anthony Jr. | 5 receptions, 66 yards, 1 TD | |
| North Carolina Central | Passing | 16/26, 184 yards, 1 INT | |
| Rushing | Jordan Freeman | 9 carries, 72 yards | |
| Receiving | Ryan McDaniel | 6 receptions, 72 yards |
See also: 2021 Marshall Thundering Herd football team.