| Year: | 2021 |
| Team: | James Madison Dukes |
| Sport: | football |
| Conference: | Colonial Athletic Association |
| Short Conf: | CAA |
| Statsrank: | 3 |
| Fcscoachrank: | 3 |
| Record: | 12–2 |
| Conf Record: | 7–1 |
| Head Coach: | Curt Cignetti |
| Hc Year: | 3rd |
| Off Coach: | Mike Shanahan |
| Oc Year: | 1st |
| Off Scheme: | Spread |
| Def Coach: | Corey Hetherman |
| Dc Year: | 3rd |
| Def Scheme: | 4–3 |
| Stadium: | Bridgeforth Stadium |
| Champion: | CAA co-champion |
| Bowl: | NCAA Division I Semifinal |
| Bowl Result: | L 14–20 vs. North Dakota State |
The 2021 James Madison Dukes football team represented James Madison University as a member of the Colonial Athletic Association (CAA) during the 2021 NCAA Division I FCS football season. They were led by third-year head coach Curt Cignetti and played their home games at Bridgeforth Stadium.
On November 6, 2021, James Madison announced that this will be the last season for the team in the CAA and join the Sun Belt Conference (FBS) on July 1, 2022.