See main article: 2021 Internazionali di Tennis Città di Perugia.
Tomislav Brkić and Ante Pavić were the defending champions[1] but chose not to defend their title.
Vitaliy Sachko and Dominic Stricker won the title after defeating Tomás Martín Etcheverry and Renzo Olivo 6–3, 5–7, [10–8] in the final.